Life Sciences Transformational R&D Investment Fund (TRIF) Pilot

The Life Sciences Transformational R&D Investment Fund Pilot is a newly established £50 million capital grant opportunity. It aims to boost research and development (R&D) within the UK's Life Sciences sector by supporting large-scale investments focused on innovation and strengthening health resilience. The fund prioritises projects with the potential to generate economic benefits. This is a new fund that works alongside the separate Life Sciences Innovative Manufacturing Fund (LSIMF). Projects with a total cost (including capital expenditure) of at least £100 million are eligible to apply. The grant awarded is set at the minimum level necessary to ensure your project proceeds while adhering to UK subsidy regulations, typically ranging from 10-20% of total project costs. For instance, a project with a total cost of £100 million would generally receive a grant of £10-20 million.

Your Company To be considered eligible for the TRIF Pilot, your company must meet the following requirements: • Be a  UK-registered  and  wholly private sector  business. • Operate as a product developer , contract development and manufacturing organisation (CDMO) , or generics manufacturer . • Provide  two years of audited accounts  for the applicant company or parent entity. If unavailable, you must demonstrate that the remaining project funding has been secured. • Show a  track record  of successfully developing or manufacturing medicines or medical devices, either in the UK or internationally. Your Project To be eligible for the fund, your R&D project must: • Have a total cost (including eligible capital and non-capital costs) of at least £100m . • Be  located in the UK . • Be primarily a capital investment . • Be a single company investment (as opposed to forming a partnership between companies or other types of organisations) • Be dependent on the grant to proceed. Projects that would otherwise not occur, be delayed (by three years or more), scaled down, or relocated overseas without the grant may be eligible.

The TRIF Pilot is currently accepting Expressions of Interest (EOIs). To participate, select the button above and fill out the online form through the portal. If you meet the TRIF eligibility criteria, you will receive an email, and a guidance session may be scheduled if helpful. Afterwards, you will be requested to submit Application Form 1, which serves as the formal EOI. The application process has three sections: Section 1: Application Form 1 - Expression of Interest (EOI) We will use the EOI to evaluate your eligibility and identify projects that align with the Fund’s objectives. Eligible projects will be invited to the next stage via email. Section 2: Objective 1 – innovation and health resilience assessment We will assess the health resilience and innovation benefits of your project using: (a) Application Form 1 • You will need to describe the innovation and health resilience benefits of your project. This stage is assessed by a panel of cross-government officials. (b) Panel interview • You will be required to give a brief 10-minute presentation on the benefits of your project, followed by a short question-and-answer session. • The interview will be hosted by a panel of independent experts who will further assess your project’s health resilience and innovation benefits, as well as project viability and deliverability. Section 3: Objective 2 - financial and economic assessment (a) Application Form 2 • If you are successful following the objective 1 assessment, you will be invited to complete Application Form 2. Questions will cover eligibility, company and project specifics and financial information, markets and economic impacts and project risks​. • You will be required to provide further documentation to evidence your company’s financial position, eligibility and project viability. (b) Due diligence We will assess whether your grant request offers good value for money, ensure compatibility with subsidy control regulations, validate what would happen without a grant, and confirm the project’s deliverability, employment outputs and your ability to finance it. You may be required to provide further documentation to evidence your company’s financial position, eligibility and project deliverability. Questions? If you have any questions, please email TRIF@officeforlifesciences.gov.uk .